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GHK-Cu has real gene-modulation data (Pickart and Margolina documented over 4,000 regulated genes in vitro) but topical penetration through intact skin remains a credibility-limiting unresolved question

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What Patients Actually Report Anecdotally (and I want to underscore that word), compounding pharmacy practice sees: Reduced gut symptoms within 3 to 6 weeks for a meaningful subset of patients Improved tolerance to previously reactive foods in some cases, though this is highly variable and unpredictable Stable symptom maintenance in patients with already-controlled IBD Generally good tolerability with few reported adverse effects These are observational reports, not controlled-trial outcomes