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Mitochondrial function was severely compromised on multiple levels, including abnormalities in mitochondrial biogenesis (PGC1α), nutrient sensors regulating fatty-acid entry into mitochondria (pAMPK/AMPK, SirT3, CPT1b), mitochondrial β-oxidation of fatty-acids (HADHA, PPARα), electron transport chain complexes (I, II, III, V), ATP synthesis (ATP5A), and mitophagy (PINK1)
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What is restricted is marketing them as treatments, and whether a licensed pharmacy may prepare a given substance, which is governed by the compounding framework